Potassium channel opening: a subtle two-step
نویسندگان
چکیده
منابع مشابه
Initial steps in the opening of a Shaker potassium channel.
The structural model of a K(V) (K(+)-selective, voltage-gated) channel in the open state is known (Protein Data Bank ID code 2R9R). Each subunit of the channel has four negatively charged residues distributed in the transmembrane segments S1, S2, and S3 that bind to and facilitate the movement within the membrane of the positively charged, voltage-sensing residues of S4. When extrapolated to th...
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To determine how intracellular Ca 2 ! and membrane voltage regulate the gating of large conductance Ca 2 ! -activated K ! (BK) channels, we examined the steady-state and kinetic properties of mSlo1 ionic and gating currents in the presence and absence of Ca 2 ! over a wide range of voltage. The activation of unliganded mSlo1 channels can be accounted for by allosteric coupling between voltage s...
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BACKGROUND Adenosine can initiate ischemic preconditioning, and mitochondrial ATP-sensitive potassium (K(ATP)) channels have emerged as the likely effectors. We sought to determine the mechanistic interactions between these 2 observations. METHODS AND RESULTS The mitochondrial flavoprotein oxidation induced by diazoxide (100 micromol/L) was used to quantify mitochondrial K(ATP) channel activi...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2009
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2009.174730